Synthesis and anti-histaminic activity of some novel pyrimidines

Novel Pyrimidines were prepared by the condensation of Chalcones of 4 -piperazine acetophenone with guanidine HC1. The structures of the synthesized compounds RP 1-5 were assigned on the basis of Elemental analysis, IR, [1]H NMR and Mass spectroscopy. These compounds were also screened for antihistaminic activity. The recorded% of histamine inhibition showed significant antihistaminic activity when compared to the reference antihistaminic drug mepiramine

13C and 1H nuclear magnetic resonance spectral studies on some 1,4-disubstituted piperazine derivatives

[13]C AND [1]H chemical shifts are reported for a number of 1-[p-substituted phenacyl]-4-arylpiperazine analogues. The present NMR data clearly demonstrate the easy distinction of these analogues utilizing [13] C NMR. A similar differentiation using [1]H NMR was not possible as some of these analogues displayed complex and overlapping proton resonances particularly in the aromatic region. Thus, in the present study emphasis has been given to the [13]C NMR assignments. The methods and techniques followed for the assignments are described

Synthesis of N, N'-bis [N-4-N-methylcarbamyl-oxymethylthioxanthen-9-on-1-yI aminoethyI] piperazine of possible antitumor activity

N,N'-bis [N-[4-hydroxymethylthioxanthen-9-on-1-yl] piperazine and its N-methylcarbamate derivative have been synthesized. The compounds are considered a combination of two molecules of the antischistosomal drug, hycanthone. The two compounds are possibly active as antitumor as well as antischistosomal